Anticancer activity of benzoxazole derivative (2015 onwards): a review
نویسندگان
چکیده
منابع مشابه
AJI9561, a new cytotoxic benzoxazole derivative produced by Streptomyces sp.
(Traders) 1.0%, yeast extract 0.1%, and CaCO3 0.2% (pH 7.2). The fermentation was carried out at 28°C on a rotary shaker (180 rpm) for 96 hours. The culture broth of Streptomyces sp. AJ9561 (5 liters) was filtered to obtain mycelium, which was extracted with acetone (3 liters) at room temperature. The extract was concentrated in vacuo to an aqueous suspension, which was extracted with EtOAc (50...
متن کاملAnticancer activity, toxicity and pharmacokinetic profile of an indanone derivative.
The present study describes anticancer effect of gallic acid based indanone derivative (1). Indanone 1 exhibited in vivo anticancer activity against Erhlich ascites carcinoma in Swiss albino mice by inhibiting tumor growth by 54.3% at 50 mg/kg b.wt. It showed antitubulin effect by inhibiting tubulin polymerase enzyme. In cell cycle analysis, it inhibited G2/M phase and induced apoptosis. It sig...
متن کاملPyrimidine containing furanose derivative having antifungal, antioxidant, and anticancer activity
BACKGROUND A series of 6-(substituted aldehyde)-3,4-dihydro-1-(tetrahydro-3,4-dihydroxy-5-(hydroxymethyl) furan-2-yl)-4-phenylpyrimidine-2(1H)-one derivative (6A-6P) was synthesized from the 6-(substituted aldehyde)-4-phenylpyrimidine-2(1H)-one derivative (5A-5P) through following reaction mechanisms Claisen-Schmidt, Cyclization, and Satos fusion. The structures of the synthesized compounds wer...
متن کاملAnti-influenza Activity of a Novel Polyoxometalate Derivative (POM-4960)
There are many effective chemothereutic agents used in influenza disease which some of them inhibit virus replication by interfering with FluV (influenza virus) viral binding or its penetration into cell membrane. A series of polyoxometalates compounds such as POM-523 and PM-504 have been synthesized and have showed inhibitory effects on viruses. In this study we examined anti influenza activit...
متن کاملIdentification of a phenanthrene derivative as a potent anticancer drug with Pim kinase inhibitory activity.
Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in malignant lesions, but not in normal tissues, of endoderm-derived organs, including the pancreas, liver, colon, and stomach. Furthermore, the development of hepatocellular carcinoma is accelerated in mice expressing Pim-3 transgene selectively in the liver when these mice are treated with a hepatocarcinoge...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Future Journal of Pharmaceutical Sciences
سال: 2020
ISSN: 2314-7253
DOI: 10.1186/s43094-020-00115-0